{"id":10137,"date":"2024-01-10T21:19:58","date_gmt":"2024-01-10T13:19:58","guid":{"rendered":"https:\/\/taiwanfullarch.com.tw\/?p=10137"},"modified":"2026-03-24T16:23:44","modified_gmt":"2026-03-24T08:23:44","slug":"%e2%98%85is-dental-implant-placement-possible-after-the-use-of-osteoporosis-medications","status":"publish","type":"post","link":"https:\/\/taiwanfullarch.com.tw\/?p=10137","title":{"rendered":"\u2605Is Dental Implant Placement Possible After the Use of Osteoporosis Medications?"},"content":{"rendered":"\t\t
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Cases Study<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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\u258b The First Taiwanese Dentist Published in the New England Journal of Medicine<\/p>

Dr. Chen Yu-Feng published a case report related to Medication-Related Osteonecrosis of the Jaw in May 2023 in the The New England Journal of Medicine.<\/p>

The New England Journal of Medicine is a world-renowned medical journal, and Dr. Chen is the first dentist from Taiwan to have a publication accepted in this journal.<\/p>

Article link:
https:\/\/www.nejm.org\/doi\/10.1056\/NEJMicm2209172<\/p>

\u258b What is MRONJ?<\/p>

MRONJ is a serious complication associated with antiresorptive therapy (commonly referred to as \u201cbone injections\u201d). It typically occurs in patients receiving these medications who subsequently undergo invasive dental procedures, such as tooth extraction.<\/p>

Clinical manifestations may include infection, pain, intraoral or extraoral fistula formation, and bone necrosis.<\/p>

\u258b Antiresorptive Medications<\/p>

Patients with osteoporosis or bone metastases from cancer often require antiresorptive medications as part of their treatment. Commonly used drugs include bisphosphonates (BP):<\/p>

Alendronate (Fosamax)
Risedronate (Actonel \/ Reosteo)
Pamidronate (Aredia)
Ibandronate (Bonviva)
Zoledronate (Zometa, Aclasta)<\/p>

The mechanism of action of bisphosphonates involves binding to bone and interfering with osteoclast activity, leading to inhibition of bone resorption and osteoclast apoptosis.<\/p>

In contrast, Denosumab is not a bisphosphonate and does not bind to bone. It is a monoclonal antibody that inhibits osteoclast function.<\/p>

\u258b Contraindications for Dental Implants \u2013 Patients Receiving Antiresorptive Therapy<\/p>

According to a 2021 systematic review published in the Journal of Oral Implantology, which analyzed 32 studies, there is currently no strong evidence indicating that antiresorptive medications significantly reduce dental implant success rates.<\/p>

However, most of the included studies were retrospective, with limitations such as small sample sizes and lack of long-term follow-up, resulting in relatively low levels of scientific evidence. Additionally, most patients in these studies were taking oral bisphosphonates rather than receiving injectable forms.<\/p>

The review also investigated whether dental implant placement increases the risk of developing MRONJ, but no definitive conclusion could be drawn due to insufficient data.<\/p>

\u258b Clinical Recommendations<\/p>

Clinicians should exercise extreme caution when performing implant therapy in patients taking oral bisphosphonates. Recommended precautions include:<\/p>

Use of prophylactic antibiotics
Adoption of minimally invasive surgical techniques
Thorough informed consent regarding the risk of MRONJ<\/p>

Patients receiving injectable antiresorptive therapy (bone injections) are generally considered to have an absolute contraindication for dental implant treatment.<\/p>

Reference:
https:\/\/doi.org\/10.1563\/aaid-joi-D-19-00088<\/p>

Success Rate and Safety of Dental Implantology in Patients Treated With Antiresorptive Medication: A Systematic Review<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Cases Study \u258b The First Taiwanese Dentist Published in […]<\/p>\n","protected":false},"author":1,"featured_media":10138,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-10137","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/10137","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10137"}],"version-history":[{"count":4,"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/10137\/revisions"}],"predecessor-version":[{"id":10143,"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=\/wp\/v2\/posts\/10137\/revisions\/10143"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=\/wp\/v2\/media\/10138"}],"wp:attachment":[{"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/taiwanfullarch.com.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}